Before diving deeper into the results of the research done so far, it’s worth realizing what CBD oil really is and how it works. Once we have a basic understanding of cannabis, we can begin exploring the potential hidden in this life-giving substance like CBD.
What is CBD oil and how is it made for chronic pain?
CBD, or cannabidiol, belongs to a group of chemical compounds called cannabinoids that naturally occur in hemp (Cannabis Sativa L). CBD oil is made by combining: CBD obtained during supercritical CO2 extraction, an oil carrier (most often hemp oil or olive oil).
The recommended form of using CBD oil is to administer a few drops under the tongue through a pipette and then swallow it. This form of application of the preparation aims to obtain the effect as close as possible to the natural absorption of substances and foods by the body.
CBD acts directly on the endocannabinoid system found in the human body. It is present in the most important organs and systems of the human body, such as: brain, digestive system, liver, lungs, smooth muscles, pancreatic cells ß, blood vessels, genital organs, immune system, the nervous system. The endocannabinoid system is made up of various receptors. These include the CB1 and CB2 receptors.
The presence of cannabinoids in the body, such as CBD, activates them, which in turn triggers a series of biological reactions in the body. The amount of research into the benefits of the body’s reaction to the substances contained in cannabis continues to grow.
Positive effect of CBD therapy for chronic pain
The degree of complexity and the number of variables in the human body may make it difficult to define the action of cannabidiol. However, existing research and anecdotal evidence of users suggest a clearly positive effect of CBD therapy.
The human body is like a maze To reflect the essence and reveal the secret about the functioning of the mechanism described above, we will use a metaphor. Probably everyone knows the essence of the game, the main task of which is to lead a small ball to the center of the maze.
Now imagine CBD as a ball and the human endocannabinoid system as a maze. In its center there is a receptor that we want to activate or stop its action. Once we discover what path leads through the maze to the goal, the next achievement will be much easier than the first time. But imagine a situation where we go back to the beginning each time, the maze changes and the size of the ball (CBD dose) is modified. In this situation, it will be too large or too small to use the same known route to the destination. It’s now much easier to understand the idea that CBD goes through a series of mazes of different kinds before reaching the receptor.
Everyone’s genetics are slightly different – they have different types of mazes. In a situation where one person achieves positive results from using CBD at a certain dose, in another, the same dose may not work or be unsatisfactory. This does not mean, however, that “the ball cannot reach the end of the maze”, but says that each dose of the substance used depends on the individual preferences of the body. Accordingly, the overarching goal of scientific research on this issue is to fully understand the endocannabinoid system and get to know the full potential of CBD.
CBD and its effects in the treatment of chronic pain
Chronic pain is defined as continuous pain, usually lasting more than three months. Sleeping, eating, or even sitting at home, virtually every aspect of an individual’s life is affected by chronic pain. Prescription medications are the usual method of combating this type of condition.
Although the question of their effectiveness is hard to doubt, the side effects of their use may be of great concern. Strong pressure on the use and development of research on the use of CBD in the treatment of pain is due to its mild effect on the body. Even when using high doses. Make sure it’s third-party testing for potency and purity of contaminants, more at https://biomdplus.com/how-to-use-cbd-oil-for-pain/
CBD’s effectiveness in treating pain
CBD and chronic pain versus major surgery Surgical procedures, such as kidney transplants, are very painful in themselves. Adding to the highly toxic effects of anti-inflammatory drugs, chronic pain becomes a very serious problem. While previous studies have identified the use of CBD in the treatment of chronic pain, they have not monitored the effect of dosage and drug interactions on pain perception. Studies conducted on a group of kidney transplant patients, focusing on monitoring the results in the case of using specific doses of CBD, have produced interesting results. The results showed that two patients experienced a significant improvement in health, 4 patients had a partially positive response within the first 15 days of use, in one case no change was noted. There have been side effects reported, although not considered serious. These included nausea, dry mouth and sleepiness.
CBD for chronic pain and Ulcerative Colitis
Ulcerative colitis is a chronic condition with symptoms of prolonged abdominal and rectal pain. In order to validate the research, many techniques are used, the essence of which is to ensure that the results are not biased. The study conducted at the Oxford Academy was designed to test the effectiveness of CBD in a double-blind control. In the case of the study, neither the investigators nor the patients were aware of whether they were taking a placebo or a control dose of CBD. The study’s researchers confirmed that while the main endpoint was not met, there are indications that CBD-rich cannabis flower extract has positive effects. In the treatment of symptomatic ulcerative colitis, the obtained results have proved to be promising. This suggests continuation of research in order to reach the final conclusion.
CBD for chronic pain and rheumatoid arthritis
Already in the year 2010 it was found that rheumatoid arthritis (at that time) suffered over 2.9million people. Unfortunately, according to forecasts, this number may have increased significantly, mainly as a result of factors related to the “modern” lifestyle. Currently, the most popular form of CBD use is oral administration as an additive to an oil carrier. For this study, the researchers found that the bioavailability of CBD in arthritis was low.
Conversely, alternating CBD through the skin (in cream form) can provide more targeted relief. The report states that “topical application of CBD has therapeutic potential for the relief of pain associated with arthritis.” Additionally, it was recorded that in the rat model, “exploratory behavior was not altered by CBD, indicating a limited effect on higher brain function.” On the basis of the above studies, it can be concluded that CBD when applied transdermally gives a positive response in the body, with no negative effects.
Multiple sclerosis and chronic pain and the effectiveness of CBD In 2017
A systematic review of the therapeutic effects of cannabis and cannabinoids was published by the National Academies of Sciences. It was created based on data collected during dozens of previously conducted studies. The report looked at the effectiveness of CBD against cancer, chronic pain, epilepsy, addiction, anxiety, and other ailments. Of particular note is the conclusion that: “In adults with multiple sclerosis-related spasticity, short-term cannabinoid use improves patient-reported symptoms of spasticity.” It also added that “in adults with chronic pain, patients treated with cannabis or cannabinoids are more likely to experience clinically meaningful reductions in pain symptoms.”
The results of the work are extremely comprehensive and worth knowing in order to understand the breadth of the assessed range. They combine huge datasets along with evaluations of each as part of a larger concept. This is an undertaking that has never taken place before.
What is worth paying attention to before using CBD oil for chronic pain?
Currently, CBD hemp extract oil is widely available. Based on anecdotes of users, it receives a huge amount of positive feedback. The ongoing research is aimed at confirming the observation of users in order to move on to targeted treatment.
The above examples are only a small part of the current research work aimed at fully understanding the potential of cannabis, but we are convinced that after reading the reading it can be agreed that the results offer very promising prospects for development. As with any dietary supplement, there are many factors to consider and seek expert advice before deciding to use CBD therapy. Returning for a moment to the analogy regarding the structure of our body.
Once we become aware of the complexity and breadth of our body’s “mazes”, it is easy to see that CBD, when used as directed, can be very effective in treating chronic pain. The lack of toxicity and side effects associated with the use of CBD points a direction full of possibilities for the development of multidimensional therapies.